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Nuclear gene targeting: 

Algentech offers a cutting edge gene targeting technology that combines efficiency and precision. Our proprietary gene targeting system does not require the expression of nucleases but instead relies on the amplification of donor DNA molecules in the plant cell that are recognized by a mutidomain protein designed to bind to the donor DNA and facilitate homology search and recombination at a specific target site on the chromosome.


Applications:

Gene targeting is an essential tool for identification, insertion and modification of genes linked to high value agronomical traits. This method can be used to suppress, add, repair a gene at predefined locations in the genome or introduce a mutation within a gene of interest and facilitate the identification of genes contributing to yield, resistance to abiotic stress and pathogen aggression. We also focus on multi-gene targeting, non-GMO type of genome editing and manipulation of enzymatic pathways for industrial applications.


In the pipe:

Non-GM targeted mutagenesis tools:
As part of a continuous aim to improve our gene targeting technologies we focus on the generation of transiently expressed gene targeting units that are not integrated in the nuclear genome. The aim is to have a mutagenesis tool that is equivalent to non-GM mutagenesis methods with the added advantage of being able to direct a mutagenesis event at a specific genomic location.


Amylose-rich wheat:
Starch is made of two homopolymers: amylose and amylopectin, themselves composed of D-glucose molecules. During the process of digestion, starch is dissociated into simple sugar molecules that are readily assimilated by the body. High amylose starch is more resistant to enzymatic digestion and is used as a food supplement for its high fiber content and low glycemic index. It is also used in the textile industry, cosmetic industry, pharmaceutical industry and the production of biodegradable plastics. We are currently working on the generation amylose-rich wheat lines. This is achieved by knocking out genes encoding starch-branching enzymes in the wheat genome.